Fatty Acids and Sterols of the Tunicate, Salpa thompsoni, from the Antarctic Ocean : Chemical Composition and Hemolytic Activity

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概要

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• The fatty acid and sterol compositions of the marine tunicate Salpa thompsoni from the Antarctic Ocean are reported. Of the 21 fatty acids identified, the acids 16 : 0,20 : 5ω3,and 22 : 6ω3 were present at high concentrations. The salpa also contained various C_<26>, C_<27>, C_<28>, and C_<29> sterols with three Δ^5-sterols, i.e., cholesterol (6), (22E)-(24ξ)-24-methylcholesta-5,22-dien-3β-ol (9), and 24-methylene-cholest-5-en-3β-ol (11) as the main constituents. The presence of eight related pairs of Δ^5-sterols and 5α-stanols with identical side chains was characteristic. Desmosterol (8) and sitostanol (or C-24 epimer) (17) were found for the first time in salpas. Furthermore, the hemolytic active components of methanol extract of the salpa were examined. The total fatty acids fraction was strongly hemolytic, and detailed examination of each component acid showed the polyunsaturated acids 22 : 6ω3 and 20 : 5ω3 to be most potent.

• 社団法人日本薬学会の論文
• 1986-11-25

著者

• 稲田 昭

  Faculty of Pharmaceutical Sciences, Setsunan University

• 中西 勤

  Faculty of Pharmaceutical Sciences, Setsunan University

• 三村 務

  Faculty of Pharmaceutical Sciences, Osaka University

• 岡部 勝

  Faculty of Pharmaceutical Sciences, Osaka University

• 池川 信夫

  新潟薬科大学

• 池川 信夫

  Department Of Chemistry Tokyo Institute Of Technology

• 藤本 善徳

  Department of Chemistry, Tokyo Institute of Technology

• 藤本 善徳

  Department Of Chemistry Tokyo Institute Of Technology

• 三村 務

  大阪大学薬学部

• 岡部 勝

  大阪大薬学部

• 稲田 昭

  摂南大薬

• 松村 靖子

  Department Of Chemistry Tokyo Institute Of Technology

• 佐竹 幹雄

  Faculty of Pharmaceutical Sciences, Osaka University

• 畑 文子

  Department of Chemistry, Tokyo Institute of Technology

• 中西 務

  Faculty Of Pharmaceutical Sciences Setsunan University

• 稲田 昭

  摂南大学薬学部

• 中西 勤

  Faculty Of Pharmaceutical Sciences Osaka University

• 佐竹 幹雄

  日本水産

• Nakanishi T

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 畑 文子

  Department Of Chemistry Tokyo Institute Of Technology

• 岡部 勝

  大阪大学 薬

• 稲田 昭

  Faculty Of Pharmaceutical Sciences Setsunan University

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