Effect of Uterine Environment and Uterine Extract on Guinea Pig Sperm Metabolism

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It was demonstrated that rabbit spermatozoa was acquired the fertilizing capacity in estrous uterus. And this capacitated spermatozoa was inhibited to penetrate into the ova treating with seminal plasma. In the present report, to clear these phenomena from the biochemical aspect, it was studied that how respiration and anaerobic fructolysis of guinea pig spermatozoa were influenced by the uterine environment and uterine extract. 1) Guinea pig spermatozoa incubated in estrogen dominated uterus shows much greater respiration and anaerobic fructolysis activity than that of incubated in progesterone dominated uterus. 2) Treatment with seminal plasma caused great inhibition of respiratory activity of spermatozoa that was incubated in estrogen dominated uterus. 3) Respiration and anaerobic fructolysis stimulating factor of guinea pig spermatozoa was extracted from the estrogen treated guinea pig uterus. And from bovine uterus the same stimulating factor (a protein of approximately 50000 molecular weight estimated from the behavior on Sephadex G-75 gel filtration). 4) This bovine uterine extract recovered or accelerate the low respiratory activity of the spermatozoa for the existence of seminal plasma. From these results, it is suggested that the extract from the guinea pig and bovine uterus might play a major role in sperm respiration and anaerobic fructolysis, and further be related to capacitation process in estrous uterus.
社団法人日本薬学会の論文
1974-05-25

Effect of Uterine Environment and Uterine Extract on Guinea Pig Sperm Metabolism

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