Improved Separation of the Denopamine Metabolites Using Capillary Column Gas Chromatography-Mass Spectrometry

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概要

• 論文の詳細を見る

• Eight urinary metabolites of the positive inotropic agent denopamine, (-)-(R)-1-(p-hydroxyphenyl)-2-[(3,4-dimethoxyphenethyl) amino] ethanol, in man were separated and identified by capillary column gas chromatography-mass spectrometry. The metabolites were products of oxidative 3'-or 4'-O-demethylation and/or meta-hydroxylation followed by meta-or para-catechol O-methyltransferase-methylation. Separation of the four isomers of 1-(hydroxymethoxyphenyl)-2-[(hydroxymethoxyphenethyl) amino] ethanol was made possible by the use of a capillary column.

• 社団法人日本薬学会の論文
• 1985-06-25

著者

• 竹山 茂之

  Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• 鈴木 利一

  田辺製薬

• 竹山 茂之

  Research Laboratories Tanabe Seiyaku Co. Ltd.

• 鈴木 利一

  Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.

• 橋村 吉正

  Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.

• 橋村 吉正

  Pharmacological Research Laboratory Tanabe Seiyaku Co., Ltd.

• 鈴木 利一

  Biological Research Laboratory Tanabe Seiyaku Co. Ltd.

• 橋村 吉正

  Pharmacological Research Laboratory Tanabe Seiyaku Co. Ltd.

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