Hypocholesterolemic Activities of LK-903 and Clofibrate in Miniature Pigs, Cynomolgus Monkeys and Beagle Dogs
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概要
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The hypocholesterolemic activities of LK-903 (α-methyl-p-myristyloxycinnamic acid-1-monoglyceride) and clofibrate were examined in miniature pigs (OHMINI-875) and beagle dogs. When administered in the diet for one week, LK-903 and clofibrate were active in the miniature pig at doses of 5 and 10 mg/kg/day, respectively, whereas the two drugs showed no hypocholesterolemic activity in the beagle dog. In cynomolgus monkeys, LK-903 showed a hypocholesterolemic effect, but serum cholesterol depression was less marked than in the miniature pig.
- 社団法人日本薬学会の論文
- 1978-08-25
著者
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高島 紘毅
Research Laboratories of Tanabe Seiyaku Co., Ltd.,
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森 哲治
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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仁田 修治
Pharmacological Research Laboratory Tanabe Seiyaku Co. Ltd.
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高島 紘毅
Pharmacological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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森 哲治
Pharmacological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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大山 一明
Pharmacological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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竹山 茂之
Pharmacological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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高島 紘毅
Research Laboratories Of Tanabe Seiyaku Co. Ltd.
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竹山 茂之
Research Laboratories Tanabe Seiyaku Co. Ltd.
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森 哲治
Biological Research Laboratory Tanabe Seiyaku Co. Ltd.
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大山 一明
Pharmacological Research Laboratory Tanabe Seiyaku Co. Ltd.
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