Synthesis of 5-Alkyl-4-oxazoleacetic Acid Derivatives with Hypolipidemic Activities

スポンサーリンク

概要

• 論文の詳細を見る

• A series of 2-aryl and 2-alkyl derivatives of 5-alkyl-4-oxazoleacetic acids was synthesized and tested for hypolipidemic activity. Among them, 5-isopropyl-2-(4-fluorophenyl)-4-oxazoleacetates exhibited potent activities, being more active than clofibrate [ethyl 2-(4-chlorophenoxy)isobutyrate].

• 社団法人日本薬学会の論文
• 1988-11-25

著者

• 松本 和男

  田辺製薬医薬育成所

• 松本 和男

  Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.

• 高島 紘毅

  Research Laboratories of Tanabe Seiyaku Co., Ltd.,

• 関 雅彦

  田辺製薬医薬育成所

• 関 雅彦

  Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,

• 守屋 多聞

  Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,

• 高島 紘毅

  Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• 森 哲治

  Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• 小田原 昭男

  Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• 竹山 茂之

  Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• 高島 紘毅

  Research Laboratories Of Tanabe Seiyaku Co. Ltd.

• 竹山 茂之

  Research Laboratories Tanabe Seiyaku Co. Ltd.

• 森 哲治

  Biological Research Laboratory Tanabe Seiyaku Co. Ltd.

• 守屋 多聞

  Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.

• 小田原 昭男

  Biological Research Laboratory Tanabe Seiyaku Co. Ltd.

• 守屋 多聞

  Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co. Ltd.,

関連論文

• Practical Synthesis of Optically Pure 1- and 3-Substituted Dihydroorotic Acids
• α-イソシアノ酢酸化合物の抗植物病活性(有機化学・天然物化学-農薬-)
• Syntheses of 2-Aryl-4-(3-thienyl)imidazole Derivatives with Antiinflammatory Preperties
• Syntheses of 2-Mercapto-4-substituted Imidazole Derivatives with Antiinflammatory Properties
• 生理活性を有するイソニトリル化合物
• Syntheses and Antimicrobial Activities of α-Isocyanoacrylic Acid Derivatives
• Reaction of Phthalic Anhydrides with Methyl Isocyanoacetate : A Useful Synthesis of 1,2-Dihydro-1-oxoisoquinolines
• A Synthesis of 3-Amino-4-hydroxyquinolin-2 (1H)-one Derivatives via Oxazolo [4,5-c] quinolin-4 (5H)-ones
• Arylnaphthalene Lignans as Novel Series of Hypolipidemic Agents Raising High-Density Lipoprotein Level
• Antioxidant Properties of N-Methyl-3-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid
• アミノ酸合成--工業的見地からみた現状と最近の進歩 (アミノ酸・核酸特集)
• アスパラギン酸を用いる光学活性β-アミノ酸の立体選択的合成 : 有機化学・天然物化学
• アスパラギン酸の化学と医薬品への応用
• Synthesis of 5-Alkyl-4-oxazoleacetic Acid Derivatives with Hypolipidemic Activities
• Useful Syntheses of β-Amino-γ-ketobutyric Acid Derivatives from Aspartic Acid
• Hypocholesterolemic Activities of LK-903 and Clofibrate in Miniature Pigs, Cynomolgus Monkeys and Beagle Dogs
• Non-enzymatic Oxidation of the New Cardiotonic Agent Denopamine and Its Derivatives : Comparison with Enzymatic Oxidation
• Improved Separation of the Denopamine Metabolites Using Capillary Column Gas Chromatography-Mass Spectrometry
• 抗エイズ薬への合成的アプロ-チ
• Synthesis of Methyl 2-Isocyano-3-[3 (1H)-indolyl] acrylate and Related Compounds from 3-(Aminomethylene)-3H-indoles
• Facile Preparation of 5-(3-Indolylmethylene) hydantoins
• Preparation and Reactions of 3-(Aminomethylene)-3H-indoles
• A NEW TRANSFORMATION OF OXAZOLEACETATES INTO β-AMINOPYPPOLES
• イソニトリルの化学--α-イソシアノ酢酸誘導体を用いた合成反応
• Syntheses of 5-Substituted Oxazole-4-carboxylic Acid Derivatives with Inhibitory Activity on Blood Platelet Aggregation
• Augmentation of Tumor Immunity by 6-Mercaptopurine (6-MP) and Its Analogs in the Double Grafted Tumor System in Mice
• Antiallergic Effects of the Adrenergic β-Stimulant Trimetoquinol in Rats and Guinea Pigs
• イソニトリルの化学 : α-イソシアノ酢酸誘導体を用いた合成反応
• 生理活性を有するイソニトリル化合物
• α-アミノ酸合成の最近の進歩
• アスパラギン酸の化学と医薬品への応用

もっと見る 閉じる

スポンサーリンク