A Synthesis of 3-Amino-4-hydroxyquinolin-2 (1H)-one Derivatives via Oxazolo [4,5-c] quinolin-4 (5H)-ones

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概要

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• 3-Amino-4-hydroxyquinolin-2 (1H)-one compounds (aminocarbostyrils) were synthesized by a reaction of methyl isocyanoacetate with isatoic anhydrides in the presence of 1,8-diazabicyclo [5,4,0] undec-7-ene (DBU), followed by hydrolysis with HCl. The alkylation of oxazolo [4,5-c] quinolin-4 (5H)-ones which are the intermediates of the aminocarbostyrils and the acylation of aminocarbostyrils were also investigated. Furthermore, a variety of the quinolin-2 (1H)-one analogs showed antiallergic activity.

• 社団法人日本薬学会の論文
• 1977-10-25

著者

• 松本 和男

  田辺製薬医薬育成所

• 松本 和男

  Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.

• 鈴木 護

  Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,

• 米田 直人

  Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.

• 三好 宗次

  Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.

• 石田 柳一

  Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.

• 米田 直人

  Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.

• 鈴木 護

  Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.

• 石田 柳一

  Safety Reseach Laboratory:tanabe Seiyaku Co. Ltd.

• 三好 宗次

  Department Of Synthetic Chemistry Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd

• 米田 直人

  Research Laboratory of Applied Biochemistry

• 米田 直人

  Research Laboratory of Applied Biochemistry Tanabe Seiyaku Co., Ltd.

• 石田 柳一

  Research Laboratories of Tanabe Seiyaku Co., Ltd.

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