Bis型ビタミンB_1誘導体, Cyclobismethylenethiamineについて : (I)その生成およびο-アシル誘導体の合成
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概要
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It was found that a crystalline product (III), mp 284-289℃ (decomp), was obtained by the reaction of B_1 and formalin in the presence of sec. amine in an aqueous alkaline solution. The product (III) was treated with acid anhydride to afford the corresponding ο-acyl derivatives (IV). From chemical and physical data of III and IV, III was assumed to be a bis-type structure, 2,7,13,18-tetramethyl-6,17-diformyl-8,19-di (2-hydroxyethyl)-dipyrimido [4,5-d ; 4', 5'-m]1,10-dithia-3,7,12,16-tetraazacyclooctadeca-4,8,13,17-tetraene, consisting of molar B_1 and 2 molar formaldehyde. Depending upon its cyclic bis-type structure, III was abbreviated as cyclobismethylene-thiamine (CBMT). Formation conditions of CBMT were investigated. CBMT and its ο-acyl derivatives were proved to be little effective to promote the growth of thiamine-deficient rats.
- 1971-11-25
著者
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米田 直人
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.
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米田 直人
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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米田 直人
田辺製薬株式会社東京研究所
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松岡 雄三
田辺製薬株式会社 医薬開発研究所
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萩尾 克明
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.
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松岡 雄三
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.
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安尾 悠紀
田辺製薬株式会社化成研究所
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萩尾 克明
田辺製薬株式会社化成研究所
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萩尾 克明
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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松岡 雄三
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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