L-α-Tosylamido-β-propiolactoneの反応(第3報) : メルカプタン類との反応
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概要
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The reaction of mercaptans with L-α-tosylamido-β-propiolactone (I) derived from L-asparagine was investigated. In the presence of one molar equivalent of alkali, I reacted with mercaptans to afford N-tosyl-L-serine (III) or methyl ester (IV) of III in aqueous THF solution or methanolic solution, respectively. However, by adding catalytic amount of alkali, L-α-tosylamido-β-hydroxypropionic acid thioester (V) was obtained from the reaction mixture of I and mercaptans in THF or aqueous THF solution. No reaction was observed when I was treated with mercaptans in the presence or absence of acid catalyst.
- 1970-12-25
著者
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米田 直人
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.
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米田 直人
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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米田 直人
田辺製薬株式会社東京研究所
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藤井 利幸
田辺製薬株式会社化成研究所
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田口 善彦
田辺製薬株式会社化成研究所
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