Synthesis of Methyl 2-Isocyano-3-[3 (1H)-indolyl] acrylate and Related Compounds from 3-(Aminomethylene)-3H-indoles
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概要
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Methyl 2-isocyano-3-[3 (1H)-indolyl] acrylate (1) was synthesized in 73-75% yield by the reaction of 3-(aminomethylene)-3H-indoles (5) with methyl α-isocyanoacetate (3) in pyridine or dimethylformamide, while the reaction in methanol afforded selectively 2-(aminomethyleneamino)-3-[3 (1H)-indolyl] acrylates (6a-e) in 63-100% yields. The mechanisms of formation of 1 and 6 are discussed. Both 1 and 6a-e were hydrolyzed to N-formyl-α, β-dehydrotryptophan (8) and/or its methyl ester (2).
- 1982-01-25
著者
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米田 直人
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.
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守屋 多聞
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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米田 直人
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
-
守屋 多聞
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
-
米田 直人
Research Laboratory of Applied Biochemistry
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米田 直人
Research Laboratory of Applied Biochemistry Tanabe Seiyaku Co., Ltd.
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