Facile Preparation of optically Pure (3S)- and (3R)- 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid
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概要
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Optically pure (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (1) was easily obtained by fractional crystallization of its benzyl ester (2b) p-toluenesulfonate, which was prepared from partially racemized 1 hydrochloride, followed by catalytic debenzylation. Similarly, (3R)-1 was prepared by the same procedure. The degree of racemization during the Pictet-Spengler reaction using optically active phenylalanine was determined by ^1H-nuclear magnetic resonance (^1H-NMR) spectroscopy of the corresponding methyl ester (2a), derived from the reaction product (1), in the presence of a chiral shift reagent.
- 1983-01-25
著者
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沼波 憲一
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.
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林 公明
Research Laboratory of Applied Biochemistry Tanabe Seiyaku Co., Ltd.
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尾崎 泰彦
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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米田 直人
Research Laboratory of Applied Biochemistry
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尾崎 泰彦
Research Laboratory of Applied Biochemistry
-
林 公明
Research Laboratory of Applied Biochemistry
-
沼波 憲一
Research Laboratory of Applied Biochemistry
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