Studies on Angiotensin Converting Enzyme Inhibitors. VI. Synthesis and Angiotensin Converting Enzyme Inhibitory Activities of the Dicarboxylic Acid Derivative of Imidapril and Its Diastereoisomers
スポンサーリンク
概要
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All possible diastereoisomers of the dicarboxylic acid (10a), the biologically active form of imidapril (1), were synthesized, and their inhibitory activity against angiotensin converting enzyme (ACE) was examined. The in vitro ACE inhibitory activity of these compounds greatly depended on the configurations of the three asymmetric carbons in each molecule. The (S, S, S) isomer (10a) showed much more potent activity than the others.
- 1992-06-25
著者
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沼波 憲一
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.
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窪田 均
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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窪田 均
Research Laboratory Of Applied Biochemistry:tanabe Seiyaku Co. Ltd.
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沼波 憲一
Research Laboratory Of Applied Biochemistry:tanabe Seiyaku Co. Ltd.
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林 公明
Research Laboratory of Applied Biochemistry Tanabe Seiyaku Co., Ltd.
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大菊 典子
Biological Research Laboratory:tanabe Seiyaku Co. Ltd.
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松岡 雄三
Biological Research Laboratory:tanabe Seiyaku Co. Ltd.
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石田 柳一
Biological Research Laboratory:tanabe Seiyaku Co. Ltd.
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林 公明
Research Laboratory Of Applied Biochemistry:tanabe Seiyaku Co. Ltd.
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橋本 善勝
Biological Research Laboratory
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橋本 善勝
Biological Research Laboratory:Tanabe Seiyaku Co., Ltd.,
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林 公明
Research Laboratory of Applied Biochemistry
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沼波 憲一
Research Laboratory of Applied Biochemistry
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