Aminomethylation of Thiamine Disulfides and Formation of Cyclobismethylenethiamine from N-Aminomethylated Thiamine Disulfide
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概要
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Aminomethylation of O-benzoylthiamine disulfide (VI) with chloromethyldialkylamine (VIII), methylenebisdialkylamine (IX) and ethyl piperidinomethyl ether (Xb) was carried out to afford the corresponding N-aminomethylated compounds (XI). The reaction of thiamine disulfide (VII) with VIII or Mannich reaction of VII by the use of 37% formalin and piperidine gave N-aminomethylated compound (XIIb) without formation of the N, O-substituted compound which was reacted with both NH_2 and OH groups. Cyclobismethylenethiamine (II) was obtained by the treatment of XIIb with mercaptoethanol. The results supported that II would be formed through N-aminomethylthiamine (V).
- 1976-06-25
著者
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米田 直人
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.
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米田 直人
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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米田 直人
田辺製薬株式会社東京研究所
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安尾 悠紀
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.
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安尾 悠紀
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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米田 直人
Research Laboratory of Applied Biochemistry
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