Syntheses and Antimicrobial Activities of α-Isocyanoacrylic Acid Derivatives
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概要
- 論文の詳細を見る
A series of α-isocyanoacrylic acid derivatives were prepared via the α-formylaminoacrylic acid derivatives, which were obtained by the reaction of isocyanoacetic acids and carbonyl compounds, in order to examine their antimicrobial activities. The structureactivity relationships are presented ; it was found that (Z)-α-isocyanoacrylic acid esters possessing halogeno phenyl or thienyl groups exhibited fairly strong antifungal activities. Of these, (Z)-methyl α-isocyano-β-(2-thienyl) acrylates (5s and 5u) showed the highest activity (1.56μg/ml MIC) against Tricophyton mentagrophytes.
- 社団法人日本薬学会の論文
- 1980-08-25
著者
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松本 和男
田辺製薬医薬育成所
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松本 和男
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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鈴木 護
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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沼波 憲一
生化研
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米田 直人
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.
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山口 東太郎
Microbiological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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米田 直人
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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鈴木 護
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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山口 東太郎
Microbiological Research Laboratory Tanabe Seiyaku Co. Ltd
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米田 直人
Research Laboratory of Applied Biochemistry
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米田 直人
Research Laboratory of Applied Biochemistry Tanabe Seiyaku Co., Ltd.
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