Quinazolin-2-ones Having a Spirohydantoin Ring.I. : Synthesis of Spiro[1,2,3,4-tetrahydroquinazoline-4,4'-imidazolidine]-2,2', 5'-trione by Reaction of 1-Carbamoylisatin with Uera or Guanidine
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概要
- 論文の詳細を見る
Reaction of 1-methylcarbamoylisation (4) with urea in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) gave 4-hydroxy-3-methyl-4-ureidocarbonyl-1,2,3,4-tetrahydroquinazolin-2-one (5), which was easily cyclized with 10% HCl to afford a spirohydantoin derivative; 3-methyl-spiro[1,2,3,4-tetrahydroquinazoline-4,4'-imidazolidine]-2,2', 5'-trione (6). In a similar manner, 2'-imino-3-methyl-spiro[1,2,3,4-tetrahydroquinazoline-4.4'-imidazolidine]-2,5'-dione (8) was prepared by the reaction of 4 with guanidine, and 8 was further converted to the spirohydantoin compound 6 by treatment with sodium nitrite in acetic acid.
- 社団法人日本薬学会の論文
- 1990-11-25
著者
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鈴木 護
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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大水 博
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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山岸 正文
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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山田 義久
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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尾崎 建一
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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尾崎 健一
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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大水 博
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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鈴木 護
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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