Quinazolin-2-ones Having a Spirohydantoin Ring. III. A General and Efficient Synthesis of 3'-Substituted Spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2', 5(3'H)-triones
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概要
- 論文の詳細を見る
The reaction of 1-carbamoylisatins 2 with 2-ethyl-2-isothiourea hydrobromide in the presence of triethylamine followed by acid-catalyzed cyclization of the resulting 4-(2-ethyl-2-isothioureido)carbonyl-3,4-dihydro-4-hydroxy-2(1H)-quinazolinones 7 provides a general and high-yielding route to 3'-substituted spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2'5(3'H)-triones 8.
- 社団法人日本薬学会の論文
- 1991-07-25
著者
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岡村 公生
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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伊達 忠正
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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山岸 正文
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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山田 義久
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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尾崎 建一
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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山岸 正文
Reserch Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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尾崎 建一
Reserch Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
-
山田 義久
Reserch Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
-
鈴木 護
Reserch Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
-
鈴木 護
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
-
岡村 公生
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
-
伊達 忠正
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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