Reaction of N-(1-Phenylalkylidene)benzylamines with Benzoyl Cyanides

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概要

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• Reactions of various aldimines 4a-f with 4-nitrobenzoyl cyanide (2b) gave the Reissert-type compounds 5a-f. However, reaction of N-(1-phenylpropylidene)benzylamine (7a) with 2b gave 1-benzyl-4-hydroxy-5-imino-3-methyl-4-(4-nitrophenyl)-2-phenyl-4,5-dihydropyrrole (8a). Similar reactions of 7b, 7c, and 12 with 2b gave the pyrrole derivatives 8b, 11,and 13,respectively. Next, the reaction of N-cyclohexylidenecyclohexylamine (14) with benzoyl cyanide (2a) was reexamined. The structure of the adduct 16 was different from that of the Reissert-type compound 15 described by Dornow and Lupfert.

• 社団法人日本薬学会の論文
• 1983-08-25

著者

• 秋山 泰伸

  Meiji College Of Pharmacy

• 坂本 正徳

  Meiji College of Pharmacy

• 富松 祥郎

  Meiji College of Pharmacy

• 坂本 正徳

  明治薬科大学

• 石井 啓太郎

  Meiji College of Pharmacy

• 古見 信子

  Meiji College of Pharmacy

• 伊達 忠正

  Research Laboratories, Tanabe Seiyaku Co., Ltd.

• 石井 啓太郎

  明治薬科大学

• Sakamoto M

  Meiji College Of Pharmacy

• 伊達 忠正

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• Ishii Keitaro

  Meiji College Of Pharmacy

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