Synthesis of Novel Pyridotriazepinones as Antisecretory Agents(Organic,Chemical)
スポンサーリンク
概要
- 論文の詳細を見る
In connection with the known antisecretory activity of the benzotriazepinone (1) and the pyridylurea (2), novel pyridotriazepinones (3 and 4) have been synthesized. They were prepared from aminopyridinecarboxylic acids via several steps, and their structures were confirmed by X-ray crystallographic analysis. Attempts to synthesize the positional isomer (24) resulted in formation of the pyridotriazine (25 or 26). Some of these compounds showed moderate antisecretory activity in rats.
- 社団法人日本薬学会の論文
- 1987-01-25
著者
-
武田 幹男
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,
-
伊達 忠正
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,
-
和田 博
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
-
青江 啓一
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,
-
西端 芳彦
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,
-
和田 博
Organic Chemistry Research Laboratory Tanabe Seiyaku Co . Ltd.
-
古田土 真一
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co,. Ltd.
-
斉藤 清一
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co,. Ltd.
-
小野田 有一
Biological Research Laboratory, Tanabe Seiyaku Co,. Ltd.
-
玉木 元
Biological Research Laboratory, Tanabe Seiyaku Co,. Ltd.
-
古田土 真一
Organic Chemistry Research Laboratory Tanabe Seiyaku Co . Ltd.
-
斉藤 清一
田辺製薬研
-
斎藤 清一
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
-
斉藤 清一
Organic Chemistry Research Laboratory Tanabe Seiyaku Co . Ltd.
-
武田 幹男
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
-
伊達 忠正
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
-
西端 芳彦
Organic Chemistry Research Laboratory Tanabe Seiyaku Co . Ltd.
-
青江 啓一
Organic Chemistry Research Laboratory:tanabe Seiyaku Co. Ltd.
-
小野田 有一
Biological Research Laboratory Tanabe Seiyaku Co . Ltd.
-
Tamaki Hajime
Pharmacological Resarch Laboratory Tanabe Seiyaku Co. Ltd.
-
Tamaki H
Pharmacological Research Laboratory Tanabe Seiyaku Co. Ltd.
関連論文
- Enantioselective Reduction of meso-Cyclic-1,2-dicarboxylic Anhydrides and 1,2-Dicarboximides : Asymmetric Synthesis of Bicyclic Lactones and Hydroxylactams
- Synthesis of C-Nor Emetine Pyman
- Synthesis of 2-Phenylthiazolidine Derivatives as Cardiotonic Agents. IV. Modification of the Phenylpiperazino Moiety of 2-(Phenylpiperazino-alkoxyphenyl)thiazolidine-3-carbothloamides and the Corresponding Carboxamides(Medicinal Chemistry,Chemical)
- Synthesis of 2-Phenylthiazolidine Derivatives as Cardiotonic Agents. II. 2-(Phenylpiperazinoalkoxyphenyl)thiazolidine-3-thioearboxamides and the Corresponding Carboxamides(Medicinal Chemistry,Chemical)
- Synthesis of 3,4-Dihydro- and 1,2,3,4-Tetrahydroisoquinolines
- A New Synthetic Route to 1,5-Benzothiazepines. Synthesis of Derivatives of Diltiazem
- (-)-R-1-(4-Hydroxyphenyl)-2-[(3,4-dimethoxyphenethyl)amino]ethanol (Denopamine)の合成と絶対配置
- Asymmetric Reduction of Aromatic Ketones. I. Enantioselective Synthesis of Denopamine
- A SYNTHETIC APPROACH TO MACROLIDE MODELS BY THE REMOTE PHOTOCYCLIZATION WITH A PAIR SYSTEM OF PHTHALIMIDE AND METHYLTHIO GROUPS
- Synthesis of 2-Phenylthiazolidine Derivatives as Cardiotonic Agents; III Optically Active Isomers of Ar-Methyl-2-(2-(2-(4-phenylpiperazino)-ethoxy)phenyl)thiazolidine-3-carboxamides(Medicinal Chemistry,Chemical)
- Synthesis of 2-Phenylthiazolidine Derivatives as Cardiotonic Agents. I. 2-Phenylthiazolidine-3-thiocarboxamides(Medicinal Chemistry,Chemical)
- Synthesis of Novel Pyridotriazepinones as Antisecretory Agents(Organic,Chemical)
- Antiulcer Activity of Dehydroabietic Acid Derivatives
- Studies on 1,2,3,4-Tetrahydroisoquinolines. IV. β-Adrenoceptor Activity and Absolute Stereochemistry of (-)-5,7-Dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
- Studies on 1,2,3,4-Tetrahydroisoquinolines. III. Syntheses and β-Adrenoceptor Activities of Methyl Derivatives of Trimetoquinol
- Studies on Antiallergic Agents. I. Phenyl-substituted Heterocycles with a 5-Tetrazolyl or N-(5-Tetrazolyl) carbamoyl Group
- Quinazolin-2-ones Having a Spirohydantoin Ring. III. A General and Efficient Synthesis of 3'-Substituted Spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2', 5(3'H)-triones
- Studies on 1,2,3,4-Tetrahydroisoquinolines. VI. Reutilization of the Unwanted (R)-Isomer of (S)-(-)-5,7-Dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline (TA-073)
- Studies on 1,2,3,4-Tetrahydroisoquinolines. V. A Convenient Synthesis of (±)-5,7-Dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline (Racemic TA-073)
- Purines. LXX. An Extension of the "Phenacylamine Route" to the Syntheses of the 7-N-Oxides of 6-Mercaptopurine and 6-Methylthiopurine, and Antileukemic Activity of Some Purine N-Oxides
- Purines. LXVII. An Alternative Synthesis of Adenine 7-Oxide : N-Oxidation of the Adenine Ring Utilizing Blocking/Deblocking at the 1-Position
- Purines. LXVI. Adenine 7-Oxide : Its Synthesis, Chemical Properties, and X-ray Molecular Structure
- 4 Securinine及びVirosecurinineの全合成
- Total Synthesis of Securinine
- Asymmetric Synthesis Using Chiral Acetals : Highly Diastereoselective Nucleophilic Addition of Grignard Reagents to Chiral 1-Oxo-β-tetralone 1-Acetals
- Synthesis in the Diazasteroid Group. XXI. An Alternative Synthesis of the 8,16-Diazasteroid System
- Studies on the Syntheses of Hydrogenated Quinolines and Isoquinolines as Analgesics. XI. Synthesis of N-Methyl-6-aza-des-N-morphinan (2-Methyl-5,10b-trimethylene-1,2,3,4,4a, 5,6,10b-octahydrobenzo [h] isoquinoline).
- Structure of Securitinine.
- Convenient Synthesis of 6-(1-Acetyl-2-piperidyl)-6-hydroxy-2-cyclohexene-Δ^-acetic Acid γ-Lactone, the Key Intermediate in Total Synthesis of Securinine
- Structure of Securitinine
- Hofmann Degradations of Tetrahydrosecurinine and Tetrahydrosecurininol. Stereochemistry at C-3a of Tetrahydrosecurinine
- Synthesis and Stereochemistry in B/C Ring Juncture of Lactamcarbinol A, a Degradation Product of Securinine
- Securinineの構造
- Synthesis of the Metabolites of Clentiazem
- Asymmetric Reduction of Aromatic Ketones. II. An Enantioselective Synthesis of Methyl (2R, 3S)-3-(4-Methoxyphenyl)glycidate
- Synthesis of the Optically Active trans-Isomers of Diltiazem and Their Cardiovascular Effects and Ca-Antagonistic Activity
- Synthesis of N-Substituted C-Normorphinans and Their Pharmacological Properties
- Reactions of 3-Phenylglycidic Esters. V. Reaction of Methyl 3-(4-Methoxyphenyl) glycidate with 2-Nitroaniline and Synthesis of 1,5-Benzodiazepine Derivatives
- Reaction of 3-Phenylglycidic Esters. III. Reaction of cis-3-Arylglycidic Esters with Various Thiophenols
- Reaction of 3-Phenylglycidic Esters. IV. Reaction of Methyl 3-(4-Methoxyphenyl) glycidate with 2-Nitrophenol and Synthesis of 1,5-Benzoxazepine Derivatives
- A New Class of Nitrosoureas. IX. Synthesis and Antitumor Activity of 3-Substituted 1-(2-Chloroethyl)-3-(methyl α-D-glucopyranosid-6-yl or methyl 2-acetamido-2-deoxy-α-D-glucopyranosid-6-yl)-1-nitrosoureas
- A New Class of Nitrosoureas. VIII. Synthesis and Antitumor Activity of 3-Substituted 1-(2-Chloroethyl)-3-(trans-2-hydroxy-cyclohexyl)-1-nitrosoureas
- 15.Securitinine及びSecurinol Aの構造
- Structures of Norsecurinine and Dihydronorsecurinine
- Absolute Stereochemistry at C_ of Norsecurinine and Dihydronorsecurinine
- Structure and Stereochemistry of Norsecurinine and Dihydronorsecurinine
- 18.NorsecurinineおよびVirosineの構造
- 合成医薬品の研究(第2報) Pyrrolo[1,2-d][1,4]benzodiazepine誘導体の合成
- 合成医薬品の研究(第1報)不飽和カルボン酸アミドおよびニトリルのラクタム化反応
- Studies on the Structure-Activity Relationships of Adrenergic β-Mimetic Benzylamine Derivatives. V. 9-Aryl-1H-2,3,7,8,9,10-hexahydrobenzo [d, e] quinolines
- Studies on the Structure-Activity Relationship of Adrenergic β-Mimetic Benzylamine Derivatives. IV. Aryl-substituted 1-Aminotetralins and 1-Aminoindans
- Studies on the Structure Activity Relationship of Adrenergic β-Mimetic Benzylamine Derivatives. II. 1-Alkylamino-2-phenyl-1,2,3,4-tetrahydronaphthalenes
- Azabicycloalkanes as Analgetics. I. Synthesis of 1-Phenyl-6-azabicyclo [3,2,1] octane Derivatives
- 抗レニン活性ペプチドの合成(第1報)
- Asymmetric Hydrogenation Catalyzed by Rhodium Complex with a New Chiral Bisphosphine Derived from L-Threonine
- Studies on Pentenomycins. III. The X-Ray Crystal Structure Analysis of Monobromopentenomycin Triacetate
- Reaction of N-(1-Phenylalkylidene)benzylamines with Benzoyl Cyanides
- Partial Synthesis of Securinine
- Syntheses and Antiulcer Activities of 2-Aminonorbornene Derivatives
- DOUBLE DIELS-ALDER CYCLOADDITIONS OF 2(1H)-PYRIDONES ACTING AS DIENOPHILES
- Syntheses of 3-Substituted Pyrrole Derivatives with Antiinflammatory Activity
- Azabicycloalkanes as Analgetics. VII. 1-Phenyl-3-azabicyclo [3. 3. 1] nonanes
- Azabicycloalkanes as Analgetics. VI. 5-Phenyl-2-azabicyclo [3,2,1] octanes
- Azabicycloalkanes as Analgetics. V. 4-Phenyl-2-azabicyclo [2,2,2] octanes
- Azabicycloalkanes as Analgetics. IV. 4-Phenyl-2-azabicyclo [2,2,1] heptanes
- BENZYLIDENECYANOMETHYL-1,3-BENZAZOLES AS 1-AZA-1,3-BUTADIENES
- Isolation of Securinol A, B, and C from Securinega suffruticosa REHD. and the Structures of Securinol A and B
- PHOTOREACTION OF N-2-ALKENYLTHIOPHTHALIMIDES : 1,4-DITHIANE FORMATION BY INTRA- AND INTERMOLECULAR TWO-FOLD PHOTOREACTIONS AND THE X-RAY ANALYSIS OF THE DITHIANES
- Photoreactions of Succinimides with an N-Acyl Group in the Side Chain. Synthesis and Stereochemistry of Tricyclic Pyrrolo[1,2-α]pyrazine Ring Systems
- INTRAMOLECULAR PHOTOCYCLOADDITION OF 3-SUBSTITUTED DITHIOSUCCINIMIDES : FACILE SYNTHESIS AND THE CRYSTAL STRUCTURE OF HIGHLY STRAINED MULTICYCLIC FUSED THIETANE SYSTEM
- Azabicycloalkanes as Analgetics. II. An Improved Synthesis of 1-Phenyl-6-azabicyclo [3,2,1] octane Derivatives
- Degradations of Allosecurinine
- Optical Rotatory Dispersion and Circular Dichroism of Securinine and Allosecurinine
- 合成鎮痛剤の研究-3-
- A NEW STEREOSELECTIVE ROUTE TO γ-BUTYROLACTONES : ASYMMETRIC SYNTHESES OF (+)-trans-WHISKY AND (+)-trans-COGNAC LACTONES
- Intestinal Absorption of a New Anticholinergic Agent, Timepidium Bromide. II. Enhancement of Absorption
- Intestinal Absorption of a New Anticholinergic Agent, Timepidium Bromide. I. Various Factors Influencing Absorption
- A New Class of Nitrosoureas. VII. Synthesis and Antitumor Activity of 3-Substituted 1-(2-Chloroethyl)-3-(methyl α-D-glucopyranosid-3-yl)-1-nitrosoureas
- 環状イミン類の新しい不斉還元剤 : 不斉水素化トリアシルオキシホウ素ナトリウム
- Purines.XXXIX. : The Crystal Structure of 9-Benzyl-N^6-methoxyadenine
- Purines. XXXI. : An X-Ray Crystallographic Structure Analysis of 3-Methyladenosine p-Toluenesulfonate
- A New Class of Nitrosoureas. VI. Synthesis and Antitumor Activity of 3-Substituted-1-(2-chloroethyl)-3-(methyl-α-D-glucopyranosid-2-yl)-1-nitrosoureas
- A New Class of Nitrosoureas. V. Structure of Isomeric L-Arabinosylureas and Isomerization Thereof
- Synthesis of Bridged 2-Phenylcyclohexylamines as Potential Analgetics
- Synthesis of B/C trans-Fused Morphine Structures. VI. Mass Spectrum, Optical Rotatory Dispersion and Circular Dichroism of B/C trans-Morphine Derivatives
- On the Absolute Configuration of Securinine
- Synthesis of B/C trans-Fused Morphine Structures. IV. Synthesis of B/C trans-Isomorphine
- 抗うつ剤としてのDidenzo[b, e][1,4]diazepine誘導体の合成
- Synthesis of a B/C trans-fused Morphine Structure
- 14.B/Cトランス・モルフィン環化合物の合成
- Syntheses of Morphine-like Structures. IV. Further Studies on Addition of Borane to 9-Methylenebenzomorphan
- Syntheses of Morphin-like Structures. III. Stereochemical Control of Addition of Borane to 9-Methylenebenzomorphan
- Syntheses of Morphine-like Structures. II. 2'-Methoxy-9-hydroxymethyl-2,5-dimethyl-6,7-benzomorphan
- Syntheses of Morphine-like Structures. I. 9-Hydroxymethyl-2,5-dimethyl-6,7-benzomorphan.
- Studies on Benzoisogranatanine Derivatives. II. Synthesis of 1-Phenethyl-2,4-propano-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines.
- Alkylsulfonyltoluene Derivatives (Diuretics. II.).
- Alkylsulfonyltoluene Derivatives (Diuretics. I.).
- Highly Effective Resolution of 1,3-Dibenzyl-6-hydroxy-3,3a, 6,6a-tetrahydro-1H-furo[3,4-d]imidazole-2,4-dione, an Intermediate for Biotin, with Optically Active Amines and Reutilizatin of the Unwanted Epimer
- The Practical Resolution of (2RS, 3RS)-2-HYdroxy-3-(4-methoxyphenyl)-3-(2-nitrophenylthio)propionic Acid, a Key Intermediate for Diltiazem, with L-Lysine
- ラクタム類の研究(第16報)X線結晶解析による1-Benzyl-5-ethyl-1,2,5,6-tetrahydro-2-oxo-4-pyridineacetic Acidの分子構造