Synthesis of 3,4-Dihydro- and 1,2,3,4-Tetrahydroisoquinolines
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概要
- 論文の詳細を見る
N-Alkylthiocarbonyldopa (1a-e) and dopamine (1f-h) derivatives can be converted into the corresponding 3,4-dihydroisoquinolines (3) by treatment with 4-nitrobenzyl bromide. The NaBH_4 reduction of 1,3-disubstituted 3,4-dihydroisoquinolines (3a-e) gave 1,3-cis-1,2,3,4-tetrahydroisoquinolines (4a-e). Hydrogenation of 3a-e over PtO_2 also gave 4a-e in good yields. The synthesis of optically active 3a, i and 4a, i is also described.
- 社団法人日本薬学会の論文
- 1986-05-25
著者
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石田 昭彦
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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大石 篤郎
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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藤井 宏
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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中村 透
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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青江 啓一
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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西端 芳彦
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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絹巻 明正
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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大石 篤郎
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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中村 透
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
-
藤井 宏
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
-
絹巻 明正
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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西端 芳彦
Organic Chemistry Research Laboratory Tanabe Seiyaku Co . Ltd.
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青江 啓一
Organic Chemistry Research Laboratory:tanabe Seiyaku Co. Ltd.
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