A New Enantioselective Synthesis of (2R, 3S)-3-(4-Methoxyphenyl)glycidic Ester via the Enzymatic Hydrolysis of erythro-N-Acetyl-β-(4-methoxyphenyl)serine
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概要
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Enantioselective synthesis of (2R, 3S)-3-(4-methoxyphenyl)glycidic ester ((2R, 3S)-1) via the enzymatic hydrolysis of erythro-N-acetyl-β-(4-methoxyphenyl)serine (9) was investigated. Treatment of the obtained α-amino acid (-)-10 with NaNO_2-KBr-dilute H_2SO_4,esterification, and subsequent oxiran-ring closure of the halohydrin gave the target compound (2R, 3S)-1 with high enantiomeric excess (94% ee).
- 社団法人日本薬学会の論文
- 1993-09-15
著者
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松木 健司
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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井上 博純
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd, .
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大石 篤郎
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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大石 篤郎
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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松木 健司
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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井上 博純
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd .
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