Reaction of 3-Phenylglycidic Esters. III. Reaction of cis-3-Arylglycidic Esters with Various Thiophenols

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概要

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• The reaction of the cis-3-arylglycidic esters 2 and 10 with thiophenols (3) has been investigated. The reactivity and stereoselectivity of the oxirane ring-opening of these cis-glycidic esters were lower than those of the trans-analogues (1 and 9). These tendencies were more apparent in the 4-MeO derivative (2). On the other hand, the tin-catalyzed reaction of 2 with 3a was highly stereospecific and afforded the cis-opening product (5a).

• 1985-03-25

著者

• 井上 博純

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd, .

• 武田 幹男

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• 近田 美紀彦

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.

• 橋山 富樹

  Organic Chemistry Research Laboratory

• 橋山 富樹

  Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• 武田 幹男

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 井上 博純

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd .

• 近田 美紀彦

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 橋山 富樹

  Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.

• Hashiyama Tomiki

  Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.

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