Azabicycloalkanes as Analgetics. I. Synthesis of 1-Phenyl-6-azabicyclo [3,2,1] octane Derivatives
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概要
- 論文の詳細を見る
As part of studies on azabicycloalkanes as analgetics with narcotic antagonist activity, 1-phenyl-6-azabicyclo [3,2,1] octane derivatives have been synthesized. Bromination of the keto amide (IXa, b) followed by treatment with sodium methoxide gave the bicyclic keto lactam (XIa, b) respectively. A number of drivatives bearing various substituents on nitrogen and C_7 have been prepared from (XIa, b) for pharmacological evaluation. 6,7-endo-Dimethyl-1-(3-hydroxyphenyl)-6-azabicyclo [3,2,1] octane (XXc) and its dextro isomers exhibited analgetic activities on the order of meperidine and morphine, respectively. They also had narcotic antagonist activity with a low grade of abuse potential.
- 社団法人日本薬学会の論文
- 1976-05-25
著者
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井上 博純
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd, .
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武田 幹男
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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川森 政敏
Organic Chemistry Research Laboratory
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斉藤 清一
田辺製薬研
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斎藤 清一
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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斉藤 清一
Organic Chemistry Research Laboratory Tanabe Seiyaku Co . Ltd.
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塚本 悟郎
New Drug Research Laboratories Kanebo Ltd.
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本間 靖
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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武田 幹男
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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井上 博純
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd .
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野口 勝通
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd. :(present Address)sapporo Branch Tanab
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