Synthesis of B/C trans-Fused Morphine Structures. VI. Mass Spectrum, Optical Rotatory Dispersion and Circular Dichroism of B/C trans-Morphine Derivatives

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概要

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• Mass, optical rotatory dispersion (ORD) and circular dichroism (CD) spectra of the B/C trans-morphine derivatives have been studied in comparison with the natural (B/C cis) isomers. A characteristic difference between isomers epimeric at C_<14> was found in mass spectrum in accord with the reported observation for the cis-and trans-morphinan derivatives. The stereochemistry of C_5 of trans-dihydrocodeinone (V) was established by ORD study and its conversion to trans-dihydrocodeine (VI) by NaBH_4 reduction.

• 公益社団法人日本薬学会の論文
• 1973-09-25

著者

• 井上 博純

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd, .

• 武田 幹男

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• 釘田 博至

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.

• 釘田 博至

  田辺製薬有機研究所

• 武田 幹男

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 釘田 博至

  Organic Chemistry Research Laboratory:tanabe Seiyaku Co. Ltd.

• 井上 博純

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd .

• 釘田 博至

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

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