Synthesis of the Metabolites of Clentiazem
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概要
- 論文の詳細を見る
The metabolites of clentiazem in the urine or bile of rats and dogs were investgated. Fifteen basic, 6 acidic, 2 neutral and 4 conjugated metabolites were isolated. In the present paper, fourteen reference compounds as shown in Charts, 1,2 and 3 were synthesized to identify the structures of the metabolites in procedures fundamentally similar to those empolyed in the synthesis of the corresponding metabolites of diltiazem.
- 1994-01-15
著者
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松木 健司
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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井上 博純
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd, .
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武田 幹男
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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大塚 久男
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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原田 恒博
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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大塚 久男
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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大塚 久雄
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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仲村 進
Research Laboratory of Drug Metabolism Tanabe Seiyaku Co., Ltd.,
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我伊野 三徳
Organic Chemistry Research Laboratory Tanabe Seiyaku Co., Ltd.,
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仲村 進
Research Laboratory Of Drug Metabolism Tanabe Seiyaku Co. Ltd.
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武田 幹男
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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松木 健司
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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我伊野 三徳
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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井上 博純
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd .
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原田 恒博
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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