A New Synthetic Route to 1,5-Benzothiazepines. Synthesis of Derivatives of Diltiazem

スポンサーリンク

概要

• 論文の詳細を見る

• Several derivatives of diltiazem (9a-c) have been synthesized from the oxamate (6) through the carbon-carbon ring closure of the sulfur-stabilized benzylic anion and the ester carbonyl group, followed by stereoselective reduction of the C_3-carbonyl of the 1,5-benzothiazepine-dione (7).

• 社団法人日本薬学会の論文
• 1992-08-25

著者

• 井上 博純

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd, .

• 武田 幹男

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• 大石 篤郎

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.

• 大石 篤郎

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 原田 恒博

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• 森本 政道

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• 長沢 正明

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• 高村 則夫

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• 高村 則夫

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 武田 幹男

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 井上 博純

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd .

• 長沢 正明

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd. :tanabe Seiyaku Co. Ltd.

• 森本 政道

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 原田 恒博

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

関連論文

• Enantioselective Reduction of meso-Cyclic-1,2-dicarboxylic Anhydrides and 1,2-Dicarboximides : Asymmetric Synthesis of Bicyclic Lactones and Hydroxylactams
• Synthesis of C-Nor Emetine Pyman
• Synthesis of 1,2,3,4-Tetrahydro-β-carboline Derivatives as Hepatoprotective Agents. I. Dithiocarbamates of Several α-Amino Acids(Medicinal Chemistry,Chemical)
• Synthesis of 2-Phenylthiazolidine Derivatives as Cardiotonic Agents. IV. Modification of the Phenylpiperazino Moiety of 2-(Phenylpiperazino-alkoxyphenyl)thiazolidine-3-carbothloamides and the Corresponding Carboxamides(Medicinal Chemistry,Chemical)
• Synthesis of 2-Phenylthiazolidine Derivatives as Cardiotonic Agents. II. 2-(Phenylpiperazinoalkoxyphenyl)thiazolidine-3-thioearboxamides and the Corresponding Carboxamides(Medicinal Chemistry,Chemical)
• Synthesis of 3,4-Dihydro- and 1,2,3,4-Tetrahydroisoquinolines
• A New Method for the Preparation of 3,4-Dihydro- and 1,2,3,4-Tetrahydro-β-carbolines
• A NEW METHOD FOR THE PREPARATION OF 3,4-DIHYDRO AND 1,2,3,4-TETRAHYDRO-β-CARBOLINES
• Syntheses of Substituted L- and D-Tryptophans
• A NEW METHOD FOR THE PREPARATION OF 3,4-DIHYDRO-β-CARBOLINES
• A New Enantioselective Synthesis of (2R, 3S)-3-(4-Methoxyphenyl)glycidic Ester via the Enzymatic Hydrolysis of erythro-N-Acetyl-β-(4-methoxyphenyl)serine
• A New Synthetic Route to 1,5-Benzothiazepines. Synthesis of Derivatives of Diltiazem
• (-)-R-1-(4-Hydroxyphenyl)-2-[(3,4-dimethoxyphenethyl)amino]ethanol (Denopamine)の合成と絶対配置
• Amino Acids and Peptides. XXIII. An Asymmetric Synthesis of (R)-(-)-Laudanosine from L-3-(3,4-Dihydroxyphenyl) alanine
• Syntheses of Hexahydroindole-2,6-diones and 15,16-Dimethoxyerythrinane-3,8-dione
• Synthesis of Octahydroindole Derivatives
• Synthesis of dl-Mesembrine and Its trans Isomer
• Acid-catalyzed Cyclization of 3-Acetyl-3-(3,4-dimethoxyphenyl) adiponitrile
• Asymmetric Reduction of Aromatic Ketones. I. Enantioselective Synthesis of Denopamine
• Synthesis of 2-Phenylthiazolidine Derivatives as Cardiotonic Agents; III Optically Active Isomers of Ar-Methyl-2-(2-(2-(4-phenylpiperazino)-ethoxy)phenyl)thiazolidine-3-carboxamides(Medicinal Chemistry,Chemical)
• Synthesis of 2-Phenylthiazolidine Derivatives as Cardiotonic Agents. I. 2-Phenylthiazolidine-3-thiocarboxamides(Medicinal Chemistry,Chemical)
• Synthesis of Novel Pyridotriazepinones as Antisecretory Agents(Organic,Chemical)
• Antiulcer Activity of Dehydroabietic Acid Derivatives
• Studies on 1,2,3,4-Tetrahydroisoquinolines. IV. β-Adrenoceptor Activity and Absolute Stereochemistry of (-)-5,7-Dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
• Studies on 1,2,3,4-Tetrahydroisoquinolines. III. Syntheses and β-Adrenoceptor Activities of Methyl Derivatives of Trimetoquinol
• Studies on Antiallergic Agents. I. Phenyl-substituted Heterocycles with a 5-Tetrazolyl or N-(5-Tetrazolyl) carbamoyl Group
• Studies on 1,2,3,4-Tetrahydroisoquinolines. VI. Reutilization of the Unwanted (R)-Isomer of (S)-(-)-5,7-Dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline (TA-073)
• Studies on 1,2,3,4-Tetrahydroisoquinolines. V. A Convenient Synthesis of (±)-5,7-Dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline (Racemic TA-073)
• Studies on optically Active Amino Acids. XVIII. Studies on α-Methyl-α-amino Acids. XIV. Several Optical Properties of α-Methyl-α-amino Acids
• Synthesis of the Metabolites of Clentiazem
• Asymmetric Reduction of Aromatic Ketones. II. An Enantioselective Synthesis of Methyl (2R, 3S)-3-(4-Methoxyphenyl)glycidate
• Synthesis of the Optically Active trans-Isomers of Diltiazem and Their Cardiovascular Effects and Ca-Antagonistic Activity
• Synthesis of N-Substituted C-Normorphinans and Their Pharmacological Properties
• Reactions of 3-Phenylglycidic Esters. V. Reaction of Methyl 3-(4-Methoxyphenyl) glycidate with 2-Nitroaniline and Synthesis of 1,5-Benzodiazepine Derivatives
• Reaction of 3-Phenylglycidic Esters. III. Reaction of cis-3-Arylglycidic Esters with Various Thiophenols
• Reaction of 3-Phenylglycidic Esters. IV. Reaction of Methyl 3-(4-Methoxyphenyl) glycidate with 2-Nitrophenol and Synthesis of 1,5-Benzoxazepine Derivatives
• A New Class of Nitrosoureas. IX. Synthesis and Antitumor Activity of 3-Substituted 1-(2-Chloroethyl)-3-(methyl α-D-glucopyranosid-6-yl or methyl 2-acetamido-2-deoxy-α-D-glucopyranosid-6-yl)-1-nitrosoureas
• A New Class of Nitrosoureas. VIII. Synthesis and Antitumor Activity of 3-Substituted 1-(2-Chloroethyl)-3-(trans-2-hydroxy-cyclohexyl)-1-nitrosoureas
• Azabicycloalkanes as Analgetics. I. Synthesis of 1-Phenyl-6-azabicyclo [3,2,1] octane Derivatives
• Azabicycloalkanes as Analgetics. VII. 1-Phenyl-3-azabicyclo [3. 3. 1] nonanes
• Azabicycloalkanes as Analgetics. VI. 5-Phenyl-2-azabicyclo [3,2,1] octanes
• Azabicycloalkanes as Analgetics. V. 4-Phenyl-2-azabicyclo [2,2,2] octanes
• Azabicycloalkanes as Analgetics. IV. 4-Phenyl-2-azabicyclo [2,2,1] heptanes
• Synthesis of 3-β-D-Ribofuranosylwye, the Most Probable Structure for Wyosine from Torulopsis utilis Phenylalanine Transfer Ribonucleic Acid
• Synthesis of 1,5-Benzothiazepine Derivatives. III
• Synthesis of 1,5-Benzothiazepine Derivatives. II
• Synthesis of 1,5-Benzothiazepine Derivatives. I
• Azabicycloalkanes as Analgetics. II. An Improved Synthesis of 1-Phenyl-6-azabicyclo [3,2,1] octane Derivatives
• 4-Acylaminophenol Derivatives as Novel Lipoxygenase Inhibitors : Synthesis and Inhibitory Effect on 5-Lipoxygenase and Leukotriene B_4 Production
• 1,5-Benzothiazepine誘導体の合成(第4報)dl-cis-3-Acetoxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Hydrochlorideの光学分割
• Synthesis and Pharmacological Properties of Azido Derivatives of 1,5-Benzothiazepine Ca Antagonist
• Synthesis of 5-(Alkylamino)-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamides : Key Intermediates for the Synthesis of 3-Alkyl-9-β-D-ribofuranosylpurine Derivatives
• Amino Acids and Peptides. XX. Reduction of α-Substituted α-Diazo Esters. Convenient Synthesis of α-Hydrazinocarboxylic Acids and Their Derivatives from α-Amino Acids
• Synthesis of Luteinizing Hormone Releasing Hormone (LH-RH)
• Amino Acids and Peptides. XIX. Synthetic Study of optically Active Carene Skeleton from α-Amino Acid. Total Synthesis of (+)-2-Carene
• Stereochemical Studies. XXXVI. Stereoselective Syntheses of trans- and cis-Cinnamic Acid Esters from the Phenylalanine Derivatives
• 1 α-アミノ酸から光学活性Carene骨格の合成研究 : (+)-Car-2-eneの合成
• Solid Phase Peptide Synthesis employing Haloacylpolystyrene as a Polymer Support
• Bromoacylpolystyrene, a New Type of Polymer Support for Solid Phase Peptide Synthesis
• Chemistry of Amino Acids. VI. Studies on α-Alkyl-α-amino Acids. X. Unusual Alkyl Migration in the Hofmann Degradation of 5-(2-Dialkylaminoethyl)-5-methylhydantoin Quarternary Ammonium Hydroxide Anhydronium Base
• Studies on Optically Active Amino Acids. XV. Studies on α-Alkyl-α-amino Acids. VIII. Absolute Configuration of Optically Active α-Methylserine and 2-Amino-2-methyl-3-butenoic Acid.
• A New Class of Nitrosoureas. VII. Synthesis and Antitumor Activity of 3-Substituted 1-(2-Chloroethyl)-3-(methyl α-D-glucopyranosid-3-yl)-1-nitrosoureas
• 塩酸ジルチアゼムの開発研究
• 環状イミン類の新しい不斉還元剤 : 不斉水素化トリアシルオキシホウ素ナトリウム
• 3-Methylisoguanosine : Synthesis and Acidic Hydrolysis of the Glycosyl Bond
• A New Class of Nitrosoureas. VI. Synthesis and Antitumor Activity of 3-Substituted-1-(2-chloroethyl)-3-(methyl-α-D-glucopyranosid-2-yl)-1-nitrosoureas
• A New Class of Nitrosoureas. V. Structure of Isomeric L-Arabinosylureas and Isomerization Thereof
• Synthesis of Bridged 2-Phenylcyclohexylamines as Potential Analgetics
• Synthesis of B/C trans-Fused Morphine Structures. VI. Mass Spectrum, Optical Rotatory Dispersion and Circular Dichroism of B/C trans-Morphine Derivatives
• Synthesis of B/C trans-Fused Morphine Structures. IV. Synthesis of B/C trans-Isomorphine
• 抗うつ剤としてのDidenzo[b, e][1,4]diazepine誘導体の合成
• Synthesis of a B/C trans-fused Morphine Structure
• 14.B/Cトランス・モルフィン環化合物の合成
• Syntheses of Morphine-like Structures. IV. Further Studies on Addition of Borane to 9-Methylenebenzomorphan
• Syntheses of Morphin-like Structures. III. Stereochemical Control of Addition of Borane to 9-Methylenebenzomorphan
• Syntheses of Morphine-like Structures. II. 2'-Methoxy-9-hydroxymethyl-2,5-dimethyl-6,7-benzomorphan
• Syntheses of Morphine-like Structures. I. 9-Hydroxymethyl-2,5-dimethyl-6,7-benzomorphan.
• Studies on Benzoisogranatanine Derivatives. II. Synthesis of 1-Phenethyl-2,4-propano-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines.
• Alkylsulfonyltoluene Derivatives (Diuretics. II.).
• Alkylsulfonyltoluene Derivatives (Diuretics. I.).
• 3-Methylxanthosine : Synthesis and Acidic Hydrolysis of the Glycosyl Bond

もっと見る 閉じる

スポンサーリンク