A New Method for the Preparation of 3,4-Dihydro- and 1,2,3,4-Tetrahydro-β-carbolines
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概要
- 論文の詳細を見る
N-Alkylthiocarbonyltryptophan (2a-i) and tryptamine (2j-m) derivatives can be converted into the corresponding 3,4-dihydro-β-carbolines (3) under mild conditions by the use of alkylating or acylating agents. The NaBH_4 reduction of 1,3-disubstituted 3,4-dihydro-β-carbolines (3a-i) gave cis- (5) or trans-1,2,3,4-tetrahydro-β-carbolines (6) with satisfactory stereoselectivity. The synthesis of optically active 3a, b and 5a, b is also described.
- 社団法人日本薬学会の論文
- 1985-08-25
著者
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石田 昭彦
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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大石 篤郎
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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中村 透
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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入江 邦彦
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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大石 篤郎
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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中村 透
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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入江 邦彦
Drug Delivery System Institute Ltd. Building Of Research Institute For Bioscience The Science Univer
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