Studies on Optically Active Amino Acids. XV. Studies on α-Alkyl-α-amino Acids. VIII. Absolute Configuration of Optically Active α-Methylserine and 2-Amino-2-methyl-3-butenoic Acid.

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概要

• 論文の詳細を見る

• The absolute configuration of (+)-α-methylserine ((+)-IX) obtained from natural source, has been elucidated to be S-configuration by the chemical correlation with (+)-isovaline ((+)-VII), at the same time the absolute configuration of (+)-2-amino-2-methyl-3-butenoic acid ((+)-XI) has also been proved to be S-series. Chemical schemes employed were shown in Charts 1 and 2. Optically active hydantoins (V and VIII) used in the correlation were prepared by the direct resolution of racemic hydantoins with brucine. Preliminary examinations using racemic compounds were also reported.

• 公益社団法人日本薬学会の論文
• 1967-11-25

著者

• 高村 則夫

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• 山田 俊一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 寺島 孜郎

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 阿知波 一雄

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 高村 則夫

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 高村 則夫

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 寺島 孜郎

  Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)sagami Chemical Research Cen

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