Stereochemical Studies. XXI. Studies on α-Alkyl-α-amino Acids. XV. Application of Thermal Isocyanide-Cyanide Rearrangement to R-S Conversion of α-Methylphenylalanine

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概要

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• R-S Conversion of R(+)-α-methylphenylalanine (R(+)-V), one of the typical α-alkyl-α-amino acids, was accomplished with 75.6% retention of its optical integrity, since the R(+)-isocyanide (R(+)-X) easily derived from R(+)-V afforded the S(+)-cyanide (S(+)-XI) with 75.6% retention of configuration when a diphenyl ether solution of R(+)-X was heated at 280°. Preliminary experiments using racemic compounds were also reported in experimental part.

• 公益社団法人日本薬学会の論文
• 1973-03-25

著者

• 柴崎 正勝

  東大院薬

• 柴崎 正勝

  Faculty Of Pharmaceutical Sciences Teikyo University:(present Address)faculty Of Pharmacertical Scie

• 山田 俊一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 寺島 孜郎

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 柴崎 正勝

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 寺島 孜郎

  (財)相模中央化学研究所

• 寺島 孜郎

  Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)sagami Chemical Research Cen

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