A Formal Total Synthesis of Thienamycin from 4-Propargyl-2-azetidinone
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概要
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A mild and efficient method for the conversion of propiolic esters to β-keto esters was developed. Initially, propiolic esters were converted to β-phenylthio-α, β-unsaturated esters, which were treated with N-bromoacetamide in an aqueous solvent followed by reductive debromination with an aqueous solution of sodium sulfite, affording β-keto esters in good yields. Using this new method, a formal total synthesis of (±)-thienamycin from 4-propargyl-2-azetidinone was accomplished.
- 公益社団法人日本薬学会の論文
- 1986-04-25
著者
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柴崎 正勝
Faculty Of Pharmaceutical Sciences Teikyo University:(present Address)faculty Of Pharmacertical Scie
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西田 篤司
Faculty Of Pharmaceutical Sciences Hokkaido University
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池上 四郎
帝京大学薬学部
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池上 四郎
Faculty of Pharmaceutical Sciences, Teikyo University
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柴崎 正勝
Faculty Of Pharmaceutical Sciences Hokkaido University
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池上 四郎
Faculty Of Pharmaceutical Sciences Teikyo University
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池上 四郎
帝京大 薬
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