Novel Reactivities on tert-Butyldimethylsilyl and tert-Butyldiphenylsilyl Ethers : Application to the Synthesis of 11-epi-PGF_<2a>
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概要
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A facile 1,5-migration of tert-butyldimethylsilyl and tert-butyldiphenylsilyl groups in the Witting reaction and under other basic conditions was observed during synthetic studies on prostaglandins. A new method for the cleavage of these two silyl protecting groups to the parent alcohol was developed by the combined use of potassium superoxide and crown ether in dimethyl sulfoxide. Utilizing these new reactivities, an efficient synthesis of 11-epi-PGF_<2α> from the well known Corey lactone was successfully achieved.
- 公益社団法人日本薬学会の論文
- 1983-08-25
著者
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柴崎 正勝
Faculty Of Pharmaceutical Sciences Teikyo University:(present Address)faculty Of Pharmacertical Scie
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池上 四郎
Faculty of Pharmaceutical Sciences, Teikyo University
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柴崎 正勝
Faculty Of Pharmaceutical Sciences Hokkaido University
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鳥沢 保広
Faculty of Pharmaceutical Sciences, Teikyo University
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池上 四郎
Faculty Of Pharmaceutical Sciences Teikyo University
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鳥沢 保広
Faculty Of Pharmaceutical Sciences Teikyo University
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