4-Propargyl-2-azetidinone as a Versatile Synthon for the Synthesis of β-Lactam Antibiotics : Hydrostannation and Its Reactivities
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概要
- 論文の詳細を見る
An efficient preparation of 4-propargyl-2-azetidinone (6) from 4-phenylsulfonyl-2-azetidinone is described. This compound was converted to the ketones 14 and 16,which are the key intermediates for the synthesis of carbapenem and carbacephem antibiotics. In this transformation it was found that polar functional groups (β-lactam, OH, etc.) control the regiochemistry of hydrostannation of the internal alkyne. The reaction of epoxystannanes with formic acid to give the ketones is also described.
- 公益社団法人日本薬学会の論文
- 1986-04-25
著者
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柴崎 正勝
Faculty Of Pharmaceutical Sciences Teikyo University:(present Address)faculty Of Pharmacertical Scie
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西田 篤司
Faculty Of Pharmaceutical Sciences Hokkaido University
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池上 四郎
帝京大学薬学部
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池上 四郎
Faculty of Pharmaceutical Sciences, Teikyo University
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柴崎 正勝
Faculty Of Pharmaceutical Sciences Hokkaido University
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池上 四郎
Faculty Of Pharmaceutical Sciences Teikyo University
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池上 四郎
帝京大 薬
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