A New Efficient Method for Conversion of Corticosteroid 17α, 21-Cyclic Ortho Esters to 17α-Acyloxy-21-chloro-21-deoxy Derivatives
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概要
- 論文の詳細を見る
The reaction of corticosteroid 17α, 21-cyclic ortho esters (2) with various chloroformates (3) afforded the corresponding 17α-acyloxy-21-chloro-21-deoxy derivatives (4) in good yields. It was found that several new derivatives, 17α-acyloxy-21-chloro-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-diones (4a-g), exhibited potent vasoconstrictive activities.
- 公益社団法人日本薬学会の論文
- 1983-01-25
著者
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池上 四郎
Faculty of Pharmaceutical Sciences, Teikyo University
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菅井 三郎
Research Laboratories, Ohta Pharmaceutical Co., Ltd.
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赤星 三弥
Research Laboratories, Ohta Pharmaceutical Co., Ltd.
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赤星 三弥
太田薬品
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池上 四郎
Faculty Of Pharmaceutical Sciences Teikyo University
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菅井 三郎
Research Laboratories Ohta Pharmaceutical Co. Ltd.
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