Reactivities of Radiation-protective Aminoalkylisothiuronium Salts. I. Hydrogen Ion Liberation of 2-Aminoethylisothiuronium and 3-Amino-propylisothiuronium Bromide Hydrobromide
スポンサーリンク
概要
- 論文の詳細を見る
Hydrogen ion liberation from AET and APT was investigated. In the presence of alkali less approximately one equivalent with respect to aminoalkylisothiuronium salt, hydrogen ion liberation was observed. In the presence of alkali more than one equivalent, hydrogen ion liberation was not occured. This reaction was attributed to the intramolecular transguanylation which was accompanied with the acid dissociation of AET and APT. The rate of hydrogen ion liberation was more than twenty times fast in AET. The ratio of activation energy was 20 or 30 per cent larger in AET than in APT. In the absence of alkali, AET was transformed to 2-aminothiazoline and ammonium ion was splitted off. While the cyclization of APT was scarcely observed in the same condition.
- 社団法人日本薬学会の論文
- 1966-02-25
著者
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赤星 三弥
National Institute of Radiological Sciences
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日野 亨
千葉大 薬
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日野 亨
千葉大学薬学部
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日野 亨
National Institute of Radiological Sciences
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花木 トモコ
National Institute of Radiological Sciences
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大屋 和美
Daiichi Seiyaku Co., Ltd.
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安東 醇
Daiichi Pure Chemicals Co., Ltd.
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安東 醇
Daiichi Pure Chemicals Co. Ltd.
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花木 昭
Faculty Of Engineering Shizuoka University
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赤星 三弥
Research Laboratories, Ohta Pharmaceutical Co., Ltd.
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Hanaki A
Faculty Of Engineering Shizuoka University
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赤星 三弥
太田薬品
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大屋 和美
Developmental Research Laboratories, Daiichi Pharmaceutical Co., Ltd.,
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大屋 和美
Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.
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