Synthesis of dl-9 (O)-Methanoprostaglandin-I_1

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概要

• 論文の詳細を見る

• The synthesis of both 9 (O)-methano-6α-prostaglandin-I_1 (9 (O)-methano-6α-PGI_1) and 9 (O)-methano-6β-prostaglandin-I_1 (9 (O)-methano-6β-PGI_1) has been accomplished via the same synthetic intermediate obtainable from 1,3-cyclooctadiene. These analogs showed weak inhibitory activity in rabbit platelet aggregation induced by adenosine diphosphate. Furthermore, 9 (O)-methano-6β-PGI_1 did not show any cytoprotective action on rabbit, stomach epithelial cells at the concentration of 10^<-6 M.

• 公益社団法人日本薬学会の論文
• 1984-02-25

著者

• 池上 四郎

  Faculty of Pharmaceutical Sciences, Teikyo University

• 岡崎 徳二

  Research Laboratories, Ohta Pharmaceutical Co., Ltd.,

• 岡崎 徳二

  Faculty of Pharmaceutical Sciences, Teikyo University

• 池上 四郎

  Faculty Of Pharmaceutical Sciences Teikyo University

• 紫崎 正勝

  Faculty of Pharmaceutical Sciences, Teikyo University

• 紫崎 正勝

  Faculty Of Pharmaceutical Sciences Teikyo University:(present Address)sagami Chemical Research Cente

• 岡崎 徳二

  Research Laboratories Ohta Pharmaceutical Co. Ltd.

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