The Reductive Cyclization of 1-Methyl-3-aminoalkyloxindoles with Lithium aluminum Hydride.

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概要

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• Lithium aluminum hydride also was found to be effective as the Ladenburg method for the reductive cyclization of 3-(2-aminoethyl)-, 3-(3-aminopropyl)-1,3-dimethyl oxindole (IVa and IVc) and their N-methyl derivatives (IVb, IVd) to pyrrolo (and pyrido) [2,3-b] indole derivatives (Va-Vd). With a little excess of lithium aluminum hydride IVd gave a indoline derivative (VIII) together with the cyclized base (Vd) though the latter of which could not be cleaved by lithium aluminum hydride even under more strenuous condition.

• 社団法人日本薬学会の論文
• 1963-05-25

著者

• 日野 亨

  Faculty of Pharmaceutical Sciences, Chiba University

• 山田 俊一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 日野 亨

  The Chemical Analysis Center Chiba University:faculty Of Pharmaceutical Sciences Chiba University

• 小川 清美

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 小川 清美

  Faculty Of Pharmaceutical Sciences University Of Tokyo

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