Pyrimidine Derivatives. II. New Synthesis and Reactions of 4-Amino-2-methylthiopyrimidine Derivatives

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概要

• 論文の詳細を見る

• 4-Amino-2-methylthiopyrimidine derivatives (4) were synthesized by the cyclization of 3-cyano-2-methylisothiourea (2) with ketones (3). Oxidation of 4 produced 4-amino-2-methylsulfinyl or 2-methylsulfonylpyrimidine derivatives (7 or 8). Amination of 7 or 8 gave hypoglycemic 2-(1-piperazinyl) pyrimidines (1). Compounds 4 were converted to 4 (3H)-pyrimidinone derivatives (12). Derivatives 1 were also synthesized via 12.

• 社団法人日本薬学会の論文
• 1981-04-25

著者

• 山田 俊一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 山田 俊一

  東京大学

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 関谷 哲雄

  Research Laboratory, Mitsubishi Yuka Pharmaceutical Co., Ltd.

• 畑 俊輔

  Research Laboratory, Mitsubishi Yuka Pharmaceutical Co., Ltd.

• 平沼 英敏

  Research Laboratory, Mitsubishi Yuka Pharmaceutical Co., Ltd.

• 内出 政之

  Research Laboratory, Mitsubishi Yuka Pharmaceutical Co., Ltd.

• 関谷 哲雄

  Pharmaceuticals Laboratory, Research Center, Mitsubishi Kasei Corporation

• 畑 俊輔

  Research Laboratory Mitsubishi Yuka Pharmaceutical Co. Ltd.

• 関谷 哲雄

  Pharmaceuticals Laboratory Research Center Mitsubishi Kasei Corporation

• 内出 政之

  Research Laboratory Mitsubishi Yuka Pharmaceutical Co. Ltd.

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