Ind. -N-Alkylation of Tryptophan and Synthesis of 1-Alkyltryptophan Hydrazides

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概要

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• A convenient method for the synthesis of 1-alkyltryptophans is described. The proof of ind. -N-alkylation was obtained from several data. Effect of 1-alkyl substitution of indole was observed on the ultraviolet spectra of 1-alkytryptophans. It was confirmed by debenzylation of L-1-benzyltryptophan in liquid ammonia that no racemization had occurred in the alkylation. 1-Alkyltryptophans were converted to hydrazides via methyl ester hydrochlorides in good yields.

• 公益社団法人日本薬学会の論文
• 1965-01-25

著者

• 山田 俊一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 塩入 孝之

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 板谷 泰助

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 塩入 孝之

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 原 健

  Teijin Institute for Bio-medical Research

• 松枝 礼

  New Lead Research Laboratories Sankyo Co. Ltd.

• 原 健

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 松枝 礼

  Faculty of Pharmaceutical Sciences, University of Tokyo

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