Stereochemical Studies. XXVII. Total Synthesis of (+)-Mesembrine with Asymmetric Synthesis using Proline Derivative

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概要

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• Asymmetric synthesis of 4,4-disubstituted 2-cyclohexenone with enamine alkylation was successfully applied to the total synthesis of (+)-mesembrine. The assignment of the absolute configuration for synthetic (+)-mesembrine was consistent with the configuration of natural (-)-mesembrine determined by X-ray crystallography.

• 公益社団法人日本薬学会の論文
• 1973-10-25

著者

• 山田 俊一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 大谷 元治

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 大谷 元治

  Tokyo Research Laboratories Kowa Company Ltd.

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