Amino Acids and Peptides. XXX. Phosphorus in Organic Synthesis. XVII. Application of Diphenyl Phosphorazidate (DPPA) and Diethyl Phosphorocyanidate (DEPC) to Solid-phase Peptide Synthesis
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概要
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Two coupling reagents for peptide synthesis, diphenyl phosphorazidate (DPPA) and diethyl phosphorocyanidate (DEPC), were tested using the solid-phase method. The reactivities of DPPA and DEPC were examined by coupling Boc-Ile with Gly-resin. In a comparison of these reagents with DCCD, these reagents showed higher reactivity than DCCD in DMF. The N-Boc derivative of melanocyte release inhibiting hormone was synthesized in good yield by the solid-phase method using these reagents. Racemization during fragment condensation on the polymer support was examined by coupling Boc-Gly-L-Ala with Leu-resin (Izumiya test).
- 社団法人日本薬学会の論文
- 1980-10-25
著者
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山田 俊一
Faculty of Pharmaceutical Sciences, University of Tokyo
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塩入 孝之
Faculty of Pharmaceutical Sciences, Nagoya City University
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山田 俊一
東京大学
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山田 俊一
Faculty Of Pharmaceutical Sciences University Of Tokyo
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塩入 孝之
Faculty Of Pharmaceutical Sciences Nagoya City University
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伊古田 暢夫
Faculty of Pharmaceutical Sciences, University of Tokyo
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伊古田 暢夫
National Institute Of Radiological Sciences
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