Stereochemical Studies. VI. Steric Course of Intramolecular Alkylations using optically Active Amine Derivatives

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概要

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• The following C-C bond formation from C-N bond were stereochemically investigated. The reaction of (S)-XII with Na_2S_2O_4,(S)-XIII with HgO and α-elimination of (S)-XIV, all gave (R)-XV in 50-70% yields with about 30% retention of configuration. Reaction of (R)-XVI with HgO afforded (S)-XVIII with the same degree of retention of configuration. Preliminary experiments on racemic compounds are also reported.

• 公益社団法人日本薬学会の論文
• 1970-06-25

著者

• 山田 俊一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 寺島 孜郎

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 寺島 孜郎

  (財)相模中央化学研究所

• 寺島 孜郎

  Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)sagami Chemical Research Cen

• 我妻 光吉

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 我妻 光吉

  Faculty Of Pharmaceutical Sciences University Of Tokyo

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