Pyrimidine Derivatives. VI. Synthesis of 2-(1-Piperazinyl)-5,6-polymethylenepyrimidine Derivatives and Determination of Their Hypoglycemic Activity

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概要

• 論文の詳細を見る

• As part of our studies on pyrimidine derivatives, 27 4-alkyl-2-(1-piperazinyl)-5,6-polymethylenepyrimidines and structurally related derivatives were synthesized, and their hypoglycemic activities were examined in mice treated with 2-deoxy-D-glucose. Most of the derivatives showed higher activity at a dose of 30 mg/kg p.o. than tolbutamide at a dose of 100 mg/kg p.o. The structure-activity relationships are discussed.

• 社団法人日本薬学会の論文
• 1983-07-25

著者

• 山田 俊一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 山田 俊一

  東京大学

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 畑 俊輔

  Research Laboratory, Mitsubishi Yuka Pharmaceutical Co., Ltd.

• 金山 敏司

  Pharmaceuticals Laboratory, Resaerch Center, Mitsubishi Kasei Corporation

• 関谷 哲雄

  Pharmaceuticals Laboratory, Research Center, Mitsubishi Kasei Corporation

• 畑 俊輔

  Research Laboratory Mitsubishi Yuka Pharmaceutical Co. Ltd.

• 関谷 哲雄

  Pharmaceuticals Laboratory Research Center Mitsubishi Kasei Corporation

• 金山 敏司

  Pharmaceuticals Laboratory Resaerch Center Mitsubishi Kasei Corporation

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