Studies on Optically Active Amino Acids. IV. A New Synthetic Approach to Chloramphenicol Base from L-Phenylalanine.

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概要

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• A new synthetic approach to chloramphenicol base (XVII) was investigated starting with L-phenylalanine (II), making use of the same configuration of the α-carbon in (II) as that of the C-2 in XVII. Preliminary experiments starting with DL-phenylalanine was also described. The synthetic route is shown in Chart 2. threo-XVI and threo-XVII, the final product in this synthetic approach, were isolated from the mixture of threo- and erythro-XV by the application of the stereoselective acyl rearrangement reaction, which is shown in Chart 3.

• 社団法人日本薬学会の論文
• 1963-09-25

著者

• 山田 俊一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 松尾 寿之

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 古賀 憲司

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• Koga Kenjiro

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University

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