Amino Acids and Peptides. XXIV. Phosphorus in Organic Synthesis. XIII. Application of Diphenyl Phosphorazidate (DPPA) to the Synthesis of the Protected N-Terminal Hexapeptide of Secretin

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概要

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• The diphenyl phosphorazidate (DPPA) method, a new coupling procedure in the peptide synthesis, was successfully applied to the synthesis of Z-His(Z)-Ser-Asp(OBu^t)-Gly-Thr-Phe-OBu^t (I) corresponding to sequence 1-6 of secretin. Comparison of the DPPA method with the classical azide method was made by the fragment coupling of Ser-Asp with Gly-Thr-Phe, revealing that the former may be as good as the latter.

• 公益社団法人日本薬学会の論文
• 1977-01-25

著者

• 山田 俊一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 塩入 孝之

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 塩入 孝之

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 小沢 健志

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 小沢 健志

  Faculty Of Pharmaceutical Sciences University Of Tokyo

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