Amino Acids and Peptides. XXIX. A New Efficient Asymmetric Synthesis of α-Amino Acid Derivatives with Recycle of a Chiral Reagent-Asymmetric Alkylation of a Chiral Schiff Base from Glycine

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概要

• 論文の詳細を見る

• An efficient asymmetric synthesis of D-α-amino acid derivatives (VI) has been achieved by alkylation of the Schiff base (III), prepared from glycine tert-butyl ester and (1S, 2S, 5S)-2-hydroxypinan-3-one (II), followed by hydrolytic cleavage of the alkylated Schiff base (V). The chiral source (II) was also recovered in good yield, allowing the proliferation of the asymmetry according to the cycle of the amino acid asymmetric synthesis shown in Chart 1.

• 社団法人日本薬学会の論文
• 1978-03-25

著者

• 山田 俊一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 塩入 孝之

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 山田 俊一

  東京大学

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 塩入 孝之

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 小栗 東明

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 河合 伸高

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 河合 伸高

  Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)central Research Laboratorie

• 小栗 東明

  Faculty Of Pharmaceutical Sciences University Of Tokyo

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