Studies on Optically Active Amino Acids. XII.Synthesis, Resolution and Racemization of Bicyclic α-Amino-ketones

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概要

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• The synthesis of optically active hexahydro-1H-pyrrolizin-1-one(I)from L-proline and the resolution of hexahydro-1(5H)-indolizinone(II), hexahydro-8(5H)-indolizinone(III), and hexahydro-2H-quinolizin-1(6H)-one(IV) by means of d-3-bromo-8-camphorsulfonic acid and d-10-camphorsulfonic acid were described. Their rate constants and half-times for racemization were determined under various conditions, at 20°, and in aqueous ethanol I was found to be racemized very rapidly, while in hydrochloric acid, no racemization was observed.

• 公益社団法人日本薬学会の論文
• 1967-03-25

著者

• 山田 俊一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 古賀 憲司

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 国枝 武久

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• Koga Kenjiro

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University

• 国枝 武久

  Faculty Of Pharmaceutical Sciences Kumamoto University

関連論文

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