立体化学の研究(第32報)L-Proline誘導体を用いたEnamineの不斉誘起反応による不斉合成, ステロイドならびにテルペン合成中間体の不斉合成

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概要

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• (S)-(+)-8-methyl-5,6,7,8-tetrahydroindane-1,5-dione (VI) and (S)-(+)-8a-methyl-1,2,-3,5,6,7,8,8a-octahydro-3,8-naphthalenedione (VII) were asymmetrically synthesized from 2-methylcyclopentane-1,3-dione (IV) and 2-methylcyclohexane-1,3-dione (V) using L-proline derivatives. Asymmetric synthesis of VI or VII from 2-methyl-2- (3-oxobutyl) cyclorentane-1,3-dione (X) or 2-methyl-2- (3-oxobutyl) cyclohexane-1,3-dione (XI) was also carried out under various reaction conditions. The reaction path of this asymmetric synthesis is discussed.

• 社団法人日本薬学会の論文
• 1975-01-25

著者

• 山田 俊一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 広井 邦雄

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 長沢 一男

  東京大学薬学部

• 広井 邦雄

  東京大学薬学部

• 山田 俊一

  東京大学薬学部

• 高橋 久紀

  東京大学薬学部

• 長沢 一男

  北海道薬大

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• 立体化学の研究(第33報)L-Proline誘導体を用いたEnamineの不斉誘起反応による不斉合成(-)-Bisdehydroestrone Methyl Etherの不斉合成
• 立体化学の研究(第32報)L-Proline誘導体を用いたEnamineの不斉誘起反応による不斉合成, ステロイドならびにテルペン合成中間体の不斉合成
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