Amino Acids and Peptides. IX. Phosphorus in Organic Synthesis. IV. Diphenyl Phosphorazidate. A New Convenient Reagent for the Peptide Synthesis

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概要

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• Preliminary investigations on the interaction between diethyl phosphorazidate and benzoic acid revealed that phosphoryl azides may be a convenient reagent for a modified Curtius reaction and the amide bond formation. Among phosphoryl azides, diphenyl phosphorazidate (DPPA) which was easily prepared by the action of sodium azide on diphenyl phosphorochloridate was chosen for the investigation on the racemization-free peptide synthesis. The Young test under various conditions proved that DPPA may be a new convenient reagent for the racemization-free peptide synthesis. The results are summarized in Tables.

• 公益社団法人日本薬学会の論文
• 1974-04-25

著者

• 山田 俊一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 塩入 孝之

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 塩入 孝之

  Faculty Of Pharmaceutical Sciences Nagoya City University

関連論文

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