Stereochemical Studies. IX. Asymmetric Synthesis of 2-Alkylcyclo-hexanones with Enamine Alkylation

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概要

• 論文の詳細を見る

• This paper is concerned with the asymmetric synthesis of 2-alkylcyclohexanones (VI) by alkylation of cyclohexanone enamines (III) of L-proline ester derivatives. Acrylonitrile, methyl acrylate, allyl bromide and ethyl bromoacetate were used as alkylating agents. Several reaction conditions were examined, and plausible reaction mechanisms were proposed. Rates of racemization for VIa and VIc were determined.

• 社団法人日本薬学会の論文
• 1972-02-25

著者

• 山田 俊一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 広井 邦雄

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 阿知波 一雄

  Faculty of Pharmaceutical Sciences, University of Tokyo

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