Stereochemical Studies. XIII. Determination of the Absolute Configuration of Mercaptosuccinic Acid by Chemical Correlation with Glyceraldehyde

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概要

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• The absolute configuration of mercaptosuccinic acid was unequivocally determined by its chemical correlation with glyceraldehyde via (-) N-acetyl-4-allomercapto-L-proline thiol-lactone ((-) XI), as shown in Chart 2 and Chart 3. It becomes clear that mercapto-succinic acid, with a positive rotation in water, belongs to the R-series. Our results show that Fredga's proposal, based on the method of quasi-racemate formation, is correct. This method of configurational correlation is unique since chemical correlation was performed without replacing the C-S bond with the C-O bond.

• 社団法人日本薬学会の論文
• 1972-03-25

著者

• 山田 俊一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 松尾 寿之

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 村上 泰興

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 古賀 憲司

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 村上 泰興

  東邦大学薬学部

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• Koga Kenjiro

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University

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