Stereoselective Reactions. II. Asymmetric Synthesis of β-Substituted Aldehydes by Michael Reaction using Chiral α, β-Unsaturated Aldimines

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概要

• 論文の詳細を見る

• The Michael reaction of diethyl malonate with chiral α, β-unsaturated aldimines (4), prepared from crotonaldehyde and optically active α-amino acid tert-butyl esters (3), was found to give the corresponding β-substituted aldehydes (5) in reasonably high optical yields after hydrolysis. A proposed stereochemical mechanism of the reaction is presented.

• 社団法人日本薬学会の論文
• 1979-10-25

著者

• 山田 俊一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 古賀 憲司

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 橋本 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 山田 俊一

  東京大学

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• Koga Kenjiro

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University

• 米島 伸泰

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 米島 伸泰

  Pharmaceutical Research Laboratory Kirin Brewery Co. Ltd.

• 橋本 俊一

  Faculty Of Pharmaceutical Sciences Hokkaido University

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