Asymmetric Reduction of Aromatic Ketones. II. An Enantioselective Synthesis of Methyl (2R, 3S)-3-(4-Methoxyphenyl)glycidate

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概要

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• Asymmetric reduction of some 3-keto esters (6,8,and 11) to 3-hydroxy esters (7,9,and 12) with various chiral reducing agents was investigated. The products (9 and 12) were converted to methyl (2R, 3S)-3-(4-methoxy-phenyl)glycidate (2R, 3S-3), a key intermediate in the practical enantioselective synthesis of dilitazem (1).

• 1993-04-15

著者

• 松木 健司

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• 井上 博純

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd, .

• 武田 幹男

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• 河合 昭好

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 武田 幹男

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 松木 健司

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 井上 博純

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd .

• 曽布川 正夫

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.

• 曽布川 正夫

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

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